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Si usted está tomando diazepam junto con otros medicamentos para controlar las convulsiones y tiene un aumento en su frecuencia o severidad, llame a su médico.butabarbital will lessen the extent or effect of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
efavirenz will reduce the extent or impact of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
Check Carefully (2)diazepam will increase the amount or impact of lemborexant by influencing hepatic/intestinal enzyme CYP3A4 metabolism.
diazepam and daridorexant both increase sedation. Modify Therapy/Observe Closely. Coadministration improves possibility of CNS despair, which may result in additive impairment of psychomotor general performance and result in daytime impairment.
Available knowledge from published observational experiments of pregnant Ladies exposed to benzodiazepines never report a transparent Affiliation with benzodiazepines and key start defects
rifapentine will lower the level or influence of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
fluconazole will raise the stage or influence of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
phenobarbital will decrease the level or impact of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
fentanyl transdermal and diazepam equally increase sedation. Stay clear of or click here Use Alternate Drug. Limit use to sufferers for whom choice therapy alternatives are inadequate
lemborexant, diazepam. Possibly improves effects of one other by sedation. Modify Therapy/Check Carefully. Dosage adjustment can be vital if lemborexant is coadministered with other CNS depressants simply because of doubtless additive effects.
Diazepam can have an effect on your alertness or coordination. Never travel or do other activities that involve alertness or coordination right up until you know the way diazepam has an effect on you.
Do not share diazepam with Other individuals, whether or not they've got precisely the same situation as you. It may hurt them.
Benzodiazepines for example diazepam are lipophilic and promptly penetrate membranes, Consequently fast cross over to the placenta with considerable uptake from the drug. Utilization of benzodiazepines which includes diazepam in late pregnancy, Particularly superior doses, may end up in floppy toddler syndrome.[sixty three] Diazepam when taken late in pregnancy, during the third trimester, brings about a definite hazard of a serious benzodiazepine withdrawal syndrome while in the neonate with signs or symptoms including hypotonia, and reluctance to suck, to apnoeic spells, cyanosis, and impaired metabolic responses to chilly worry.